Trafficking in persons is one of the greatest violations against humankind. Human trafficking happens locally, nationally, and internationally; with all ages, ethnicities, socioeconomic levels and genders. While any person can be lured into exploitation, children have additional vulnerabilities due to their dependence on adults and developmental issues. This presentation seeks to address human trafficking in children and youth and how the healthcare provider can be integral in the prevention, identification, and intervention of human trafficking in this population.